CELL-MEDIATED LYMPHOLYSIS
نویسندگان
چکیده
منابع مشابه
Cell-mediated Lympholysis
The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologica...
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H-2 congenic mouse strains were tested in vitro to investigate the genetic control of cell-mediated lympholysis (CML). Combinations were selected such that differences in various segments of H-2 could be examined for their ability to stimulate production of effector cells and to serve as targets for lysis. Particular emphasis was directed towards understanding the roles of LD and SD. SD-region ...
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Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited...
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Cell-mediated lympholysis (CML) reactivity against the splenocytes of the kidney donor might be a good in vitro correlate of the homograft reaction. The present study was performed in an attempt to determine whether CML nonreactivity between unrelated donor-recipient combinations occur and, if so, under what conditions. We were able to show that CML nonreactivity occurs between unrelated donor-...
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The major histocompatibility complex (MHC)' has been shown to play an important and probably essential role in the immune systems of a number of animal species ranging from mouse to man (1-3) . The murine MHC known as the H-2 complex has been divided into four major regions, and include two serological regions known as H-2K and 11-21) or K and D, which are separated by two other regions designe...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.137.5.1303